[PDF][PDF] Differential inhibition of human prostaglandin endoperoxide synthase-1 and-2 by nonsteroidal anti-inflammatory drugs
P Patrignani, MR Panara, MG Sciulli… - Journal of Physiology …, 1997 - yadda.icm.edu.pl
Monocytes/macrophages release pro-inflammatory mediators in response to tissue injury or
infection. Prostaglandins (PGs) and thromboxane (TX) A, collectively termed prostanoids,
are biologically active compounds that participate in both acute and chronic inflammation.
They are formed by two successive metabolic steps: 1) arachidonic acid (AA) is released
from membranous phospholipids by phospholipase A,(PLA) which consits of two forms,
secretory (sPLA,)(1) and cytosolic (cPLA)(2); 2) free AA is converted to PGG, and then to …
infection. Prostaglandins (PGs) and thromboxane (TX) A, collectively termed prostanoids,
are biologically active compounds that participate in both acute and chronic inflammation.
They are formed by two successive metabolic steps: 1) arachidonic acid (AA) is released
from membranous phospholipids by phospholipase A,(PLA) which consits of two forms,
secretory (sPLA,)(1) and cytosolic (cPLA)(2); 2) free AA is converted to PGG, and then to …