[HTML][HTML] The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression
AK Stoeckman, HC Towle - Journal of Biological Chemistry, 2002 - ASBMB
A high carbohydrate diet up-regulates the transcription of enzymes of triglyceride
biosynthesis (lipogenesis) in the mammalian liver. This treatment stimulates hepatic insulin
signaling, leading to transcription of sterol regulatory element-binding protein-1c (SREBP-
1c). SREBP-1c has been implicated as a major factor that up-regulates lipogenic genes in
response to carbohydrate feeding. However, we presented evidence for another factor,
carbohydrate response factor, which is also involved in this response, and we proposed a …
biosynthesis (lipogenesis) in the mammalian liver. This treatment stimulates hepatic insulin
signaling, leading to transcription of sterol regulatory element-binding protein-1c (SREBP-
1c). SREBP-1c has been implicated as a major factor that up-regulates lipogenic genes in
response to carbohydrate feeding. However, we presented evidence for another factor,
carbohydrate response factor, which is also involved in this response, and we proposed a …