Nonalcoholic fatty liver disease as a complication of insulin resistance
MF Abdelmalek, AM Diehl - Medical Clinics of North America, 2007 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) refers to a spectrum of liver damage ranging from
simple steatosis to nonalcoholic steatohepatitis, advanced fibrosis, and rarely, progression
to cirrhosis. The pathogenesis of NAFLD is thought to be related to insulin resistance and
oxidant stress. Truncal obesity, dyslipidema, hypertension, and hyperglycemia are strongly
associated with NAFLD; therefore, management of NAFLD entails identification and
treatment of metabolic risk factors, improving insulin sensitivity, and increasing antioxidant …
simple steatosis to nonalcoholic steatohepatitis, advanced fibrosis, and rarely, progression
to cirrhosis. The pathogenesis of NAFLD is thought to be related to insulin resistance and
oxidant stress. Truncal obesity, dyslipidema, hypertension, and hyperglycemia are strongly
associated with NAFLD; therefore, management of NAFLD entails identification and
treatment of metabolic risk factors, improving insulin sensitivity, and increasing antioxidant …