Transforming growth factor β in infectious disease: always there for the host and the pathogen
DR Fitzpatrick, H Bielefeldt-Ohmann - Trends in microbiology, 1999 - cell.com
DR Fitzpatrick, H Bielefeldt-Ohmann
Trends in microbiology, 1999•cell.comAt the portals of pathogen entry, there are pools of the latent form of a potent cytokine,
transforming growth factor β (TGF-β). Many infections activate these pools and stimulate
further TGF-β expression. As well as potent immunomodulation, activated TGF-β might have
important effects on pathogen entry, replication, persistence, latency and oncogenesis.
transforming growth factor β (TGF-β). Many infections activate these pools and stimulate
further TGF-β expression. As well as potent immunomodulation, activated TGF-β might have
important effects on pathogen entry, replication, persistence, latency and oncogenesis.
Abstract
At the portals of pathogen entry, there are pools of the latent form of a potent cytokine, transforming growth factor β (TGF-β). Many infections activate these pools and stimulate further TGF-β expression. As well as potent immunomodulation, activated TGF-β might have important effects on pathogen entry, replication, persistence, latency and oncogenesis.
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