[HTML][HTML] PU. 1, interferon regulatory factor 1, and interferon consensus sequence-binding protein cooperate to increase gp91phox expression
EA Eklund, A Jalava, R Kakar - Journal of Biological chemistry, 1998 - ASBMB
gp91 phox is a subunit of the phagocyte respiratory burst oxidase catalytic unit. Transcription
ofCYBB, the gene encoding gp91 phox, is restricted to terminally differentiated phagocytic
cells. An element in the proximalCYBB promoter binds a protein complex, referred to as
hematopoiesis-associated factor (HAF1), that is necessary for interferon-γ (IFNγ)-induced
gp91 phox expression. In these investigations, we determined that HAF1 was a multiprotein
complex, cross-immunoreactive with the transcription factors PU. 1, interferon regulatory …
ofCYBB, the gene encoding gp91 phox, is restricted to terminally differentiated phagocytic
cells. An element in the proximalCYBB promoter binds a protein complex, referred to as
hematopoiesis-associated factor (HAF1), that is necessary for interferon-γ (IFNγ)-induced
gp91 phox expression. In these investigations, we determined that HAF1 was a multiprotein
complex, cross-immunoreactive with the transcription factors PU. 1, interferon regulatory …