[HTML][HTML] Phosphorylation of GATA-4 is involved in α1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes
T Morimoto, K Hasegawa, S Kaburagi, T Kakita… - Journal of biological …, 2000 - ASBMB
The expression of endothelin-1 (ET-1) in cardiac myocytes is markedly induced during the
development of heart failurein vivo and by stimulation with the α 1-adrenergic agonist
phenylephrine in culture. Although recent studies have suggested a role for cardiac-specific
zinc finger GATA factors in the transcriptional pathways that modulate cardiac hypertrophy, it
is unknown whether these factors are also involved in cardiac ET-1 transcription and if so,
how these factors are modulated during this process. Using transient transfection assays in …
development of heart failurein vivo and by stimulation with the α 1-adrenergic agonist
phenylephrine in culture. Although recent studies have suggested a role for cardiac-specific
zinc finger GATA factors in the transcriptional pathways that modulate cardiac hypertrophy, it
is unknown whether these factors are also involved in cardiac ET-1 transcription and if so,
how these factors are modulated during this process. Using transient transfection assays in …