[HTML][HTML] The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities
SL Hutchinson, L Wooldridge, S Tafuro… - Journal of Biological …, 2003 - ASBMB
T lymphocytes recognize peptides presented in the context of major histocompatibility
complex (MHC) molecules on the surface of antigen presenting cells. Recognition specificity
is determined by the αβ T cell receptor (TCR). The T lymphocyte surface glycoproteins CD8
and CD4 enhance T cell antigen recognition by binding to MHC class I and class II
molecules, respectively. Biophysical measurements have determined that equilibrium
binding of the TCR with natural agonist peptide-MHC (pMHC) complexes occurs with KD …
complex (MHC) molecules on the surface of antigen presenting cells. Recognition specificity
is determined by the αβ T cell receptor (TCR). The T lymphocyte surface glycoproteins CD8
and CD4 enhance T cell antigen recognition by binding to MHC class I and class II
molecules, respectively. Biophysical measurements have determined that equilibrium
binding of the TCR with natural agonist peptide-MHC (pMHC) complexes occurs with KD …