[HTML][HTML] The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cells
AK Ghosh, S Bhattacharyya, J Varga - Journal of Biological Chemistry, 2004 - ASBMB
The pleiotropic cytokine transforming growth factor-β (TGF-β) is a potent inducer of collagen
synthesis and is implicated in the pathogenesis of fibrosis. Acting in concert with
transcriptional coactivators p300/CBP, the Smads mediate TGF-β stimulation of collagen
synthesis in human dermal fibroblasts. Little information exists regarding positive and
negative modulation of physiological TGF-β responses. Because the tumor suppressor p53
is implicated in connective tissue homeostasis, here we examined the regulation of collagen …
synthesis and is implicated in the pathogenesis of fibrosis. Acting in concert with
transcriptional coactivators p300/CBP, the Smads mediate TGF-β stimulation of collagen
synthesis in human dermal fibroblasts. Little information exists regarding positive and
negative modulation of physiological TGF-β responses. Because the tumor suppressor p53
is implicated in connective tissue homeostasis, here we examined the regulation of collagen …