[HTML][HTML] p300 Functions as a coactivator of transcription factor GATA-4
YS Dai, BE Markham - Journal of Biological Chemistry, 2001 - ASBMB
Transcription factor GATA-4 plays critical roles in controlling heart development and cardiac
hypertrophy. To understand how GATA-4 functions under diverse conditions, we sought to
identify its coactivators. We tested p300 as a coactivator in GATA-4-dependent transient
transcription assays in NIH3T3 cells and found that p300 synergistically activated GATA-4-
dependent transcription on both synthetic and natural promoters. Direct physical interactions
between the N-and C-zinc finger domains of GATA-4 and the cysteine/histidine-rich region 3 …
hypertrophy. To understand how GATA-4 functions under diverse conditions, we sought to
identify its coactivators. We tested p300 as a coactivator in GATA-4-dependent transient
transcription assays in NIH3T3 cells and found that p300 synergistically activated GATA-4-
dependent transcription on both synthetic and natural promoters. Direct physical interactions
between the N-and C-zinc finger domains of GATA-4 and the cysteine/histidine-rich region 3 …