[HTML][HTML] Characterization of the promoter of the rat sarcoplasmic endoplasmic reticulum Ca2+-ATPase 1 gene and analysis of thyroid hormone responsiveness
WS Simonides, GA Brent, MHM Thelen… - Journal of Biological …, 1996 - ASBMB
Relaxation of skeletal muscle requires the re-uptake of Ca 2+, which is mediated by the
sarcoplasmic reticulum Ca 2+-ATPase (SERCA). Thyroid hormone (T 3) stimulates the
expression of the SERCA1 isoform, which is essential for fast skeletal muscle fiber
phenotype. We have cloned and studied the first 962 base pairs of the 5′-flanking region of
the rat SERCA1 gene. This sequence was tested for T 3-regulated expression in transient
transfection experiments using COS7 cells and for binding of thyroid hormone receptor (TR) …
sarcoplasmic reticulum Ca 2+-ATPase (SERCA). Thyroid hormone (T 3) stimulates the
expression of the SERCA1 isoform, which is essential for fast skeletal muscle fiber
phenotype. We have cloned and studied the first 962 base pairs of the 5′-flanking region of
the rat SERCA1 gene. This sequence was tested for T 3-regulated expression in transient
transfection experiments using COS7 cells and for binding of thyroid hormone receptor (TR) …