Cell biology of IL-7, a key lymphotrophin
Q Jiang, WQ Li, FB Aiello, R Mazzucchelli… - Cytokine & growth factor …, 2005 - Elsevier
IL-7 is essential for the development and survival of T lymphocytes. This review is primarily
from the perspective of the cell biology of the responding T cell. Beginning with IL-7 receptor
structure and regulation, the major signaling pathways appear to be via PI3K and Stat5,
although the requirement for either has yet to be verified by published knockout
experiments. The proliferation pathway induced by IL-7 differs from conventional growth
factors and is primarily through posttranslational regulation of p27, a Cdk inhibitor, and …
from the perspective of the cell biology of the responding T cell. Beginning with IL-7 receptor
structure and regulation, the major signaling pathways appear to be via PI3K and Stat5,
although the requirement for either has yet to be verified by published knockout
experiments. The proliferation pathway induced by IL-7 differs from conventional growth
factors and is primarily through posttranslational regulation of p27, a Cdk inhibitor, and …