[HTML][HTML] Free fatty acid-induced β-cell defects are dependent on uncoupling protein 2 expression
JW Joseph, V Koshkin, MC Saleh, WI Sivitz… - Journal of Biological …, 2004 - ASBMB
Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein
(UCP2) in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell
defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo
and in vitro in UCP2 (–/–) mice/islets does not result in any loss in β-cell glucose sensitivity.
We have now assessed the mechanism of maintained β-cell function in UCP2 (–/–) mice by
exposing islets to 0.4 mm palmitate for 48 h. Palmitate treatment increased triglyceride …
(UCP2) in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell
defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo
and in vitro in UCP2 (–/–) mice/islets does not result in any loss in β-cell glucose sensitivity.
We have now assessed the mechanism of maintained β-cell function in UCP2 (–/–) mice by
exposing islets to 0.4 mm palmitate for 48 h. Palmitate treatment increased triglyceride …