The human plasma proteome holds the promise of a revolution in disease diagnosis and
therapeutic monitoring provided that major challenges in proteomics and related disciplines
can be addressed. Plasma is not only the primary clinical specimen but also represents the
largest and deepest version of the human proteome present in any sample: in addition to the
classical" plasma proteins," it contains all tissue proteins (as leakage markers) plus very
numerous distinct immunoglobulin sequences, and it has an extraordinary dynamic range in …