The structural basis of the multiple forms of human complement component C4
KT Belt, MC Carroll, RR Porter - Cell, 1984 - cell.com
KT Belt, MC Carroll, RR Porter
Cell, 1984•cell.comSummary cDNA clones of human complement components C4A and C4B alleles were
prepared from mRNA obtained from the liver of a donor heterozygous at both loci. cDNA
from one C4A allele was sequenced to give the derived complete amino acid sequence of
1722 amino acid residues of the C4 single chain precursor molecule and the estimated
sequences of the three peptide chains of secreted C4. Comparison with partial sequences of
a second C4A allele and a C4B allele has led to the tentative identification of some class …
prepared from mRNA obtained from the liver of a donor heterozygous at both loci. cDNA
from one C4A allele was sequenced to give the derived complete amino acid sequence of
1722 amino acid residues of the C4 single chain precursor molecule and the estimated
sequences of the three peptide chains of secreted C4. Comparison with partial sequences of
a second C4A allele and a C4B allele has led to the tentative identification of some class …
Summary cDNA clones of human complement components C4A and C4B alleles were prepared from mRNA obtained from the liver of a donor heterozygous at both loci. cDNA from one C4A allele was sequenced to give the derived complete amino acid sequence of 1722 amino acid residues of the C4 single chain precursor molecule and the estimated sequences of the three peptide chains of secreted C4. Comparison with partial sequences of a second C4A allele and a C4B allele has led to the tentative identification of some class differences in nucleotide sequences between C4A and C4B and of allelic differences between C4A alleles in this highly polymorphic system.
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