An immunohistochemical study of metaplastic spindle cell carcinoma, phyllodes tumor and fibromatosis of the breast
B Dunne, AHS Lee, SE Pinder, JA Bell, IO Ellis - Human pathology, 2003 - Elsevier
The diagnosis of metaplastic (sarcomatoid) carcinoma (MSC) of breast often requires
immunohistochemistry with a cytokeratin (CK) panel to distinguish them from phyllodes
tumors (PT), primary sarcomas, and fibromatoses. CK staining may be heterogeneous in
metaplastic carcinomas. The aim of the study was to investigate the theory that MSCs show
evidence of myoepithelial differentiation and to evaluate immunohistochemical markers that
may be helpful in distinguishing MSCs from PT and fibromatosis. We reviewed histology and …
immunohistochemistry with a cytokeratin (CK) panel to distinguish them from phyllodes
tumors (PT), primary sarcomas, and fibromatoses. CK staining may be heterogeneous in
metaplastic carcinomas. The aim of the study was to investigate the theory that MSCs show
evidence of myoepithelial differentiation and to evaluate immunohistochemical markers that
may be helpful in distinguishing MSCs from PT and fibromatosis. We reviewed histology and …