[HTML][HTML] The small heat shock protein αB-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation
MC Kamradt, F Chen, S Sam, VL Cryns - Journal of Biological Chemistry, 2002 - ASBMB
Myoblasts respond to growth factor deprivation either by differentiating into multinucleated
myotubes or by undergoing apoptosis; hence, the acquisition of apoptosis resistance by
myogenic precursors is essential for their development. Here we demonstrate that the
expression of the small heat shock protein αB-crystallin is selectively induced in C2C12
myoblasts that are resistant to differentiation-induced apoptosis, and we show that this
induction occurs at an early stage in their differentiation in vitro. In contrast, the expression of …
myotubes or by undergoing apoptosis; hence, the acquisition of apoptosis resistance by
myogenic precursors is essential for their development. Here we demonstrate that the
expression of the small heat shock protein αB-crystallin is selectively induced in C2C12
myoblasts that are resistant to differentiation-induced apoptosis, and we show that this
induction occurs at an early stage in their differentiation in vitro. In contrast, the expression of …