[HTML][HTML] Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormones
NM Brown, KDR Setchell - Laboratory investigation, 2001 - Elsevier
It is generally not known that most commercial rodent diets are formulated with soy protein
and deliver large daily doses of isoflavones to animals throughout their lifespan, including
the in utero period. Here, we demonstrate that isoflavones are bioavailable and show that
commercial rodent diets universally used by animal facilities lead to very high steady-state
serum isoflavone concentrations in adult rats (2613±873 ng/mL) and mice (2338±531
ng/mL), exceeding the animal's endogenous estrogen level by 30,000-to 60,000-fold. We …
and deliver large daily doses of isoflavones to animals throughout their lifespan, including
the in utero period. Here, we demonstrate that isoflavones are bioavailable and show that
commercial rodent diets universally used by animal facilities lead to very high steady-state
serum isoflavone concentrations in adult rats (2613±873 ng/mL) and mice (2338±531
ng/mL), exceeding the animal's endogenous estrogen level by 30,000-to 60,000-fold. We …