[HTML][HTML] Cloning and Functional Expression of mCCR2, a Murine Receptor for the CC Chemokines JE and FIC (∗)
T Kurihara, R Bravo - Journal of Biological Chemistry, 1996 - ASBMB
The CC chemokines human monocyte chemoattractant protein-1 and− 3 (MCP-1 and MCP-
3) and mouse JE and FIC are potent activators of monocytes. Several receptors for MCP-1
and MCP-3 have been cloned from human monocytic cell lines, and one of these receptors,
CCR2B, binds both MCP-1 and MCP-3. Thus far, no murine receptors for JE or FIC have
been reported. We have cloned a novel murine CC chemokine receptor, designated mouse
CCR2 (mCCR2), from the mouse monocyte cell line WEHI265. 1. The predicted 373-amino …
3) and mouse JE and FIC are potent activators of monocytes. Several receptors for MCP-1
and MCP-3 have been cloned from human monocytic cell lines, and one of these receptors,
CCR2B, binds both MCP-1 and MCP-3. Thus far, no murine receptors for JE or FIC have
been reported. We have cloned a novel murine CC chemokine receptor, designated mouse
CCR2 (mCCR2), from the mouse monocyte cell line WEHI265. 1. The predicted 373-amino …