Interleukin-10 regulation in normal subjects and patients with asthma
L Borish, A Aarons, J Rumbyrt, P Cvietusa… - Journal of Allergy and …, 1996 - Elsevier
Interleukin-10 or cytokine synthesis inhibitory factor has important antiinflammatory activities
in immune diseases. We speculated that diminished IL-10 production in asthma would
permit the unopposed synthesis of proinflammatory cytokines, contributing to the
development and severity of asthma. Our data demonstrate constitutive secretion of IL-10
into bronchoalveolar lavage (BAL) fluid of normal, nonasthmatic subjects (130±61 pg/ml; n=
8). Asthmatic patients' BAL fluid was characterized by diminished concentrations of IL-10 …
in immune diseases. We speculated that diminished IL-10 production in asthma would
permit the unopposed synthesis of proinflammatory cytokines, contributing to the
development and severity of asthma. Our data demonstrate constitutive secretion of IL-10
into bronchoalveolar lavage (BAL) fluid of normal, nonasthmatic subjects (130±61 pg/ml; n=
8). Asthmatic patients' BAL fluid was characterized by diminished concentrations of IL-10 …