[HTML][HTML] Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of …
T Miralem, Z Hu, MD Torno, KM Lelli… - Journal of Biological …, 2005 - ASBMB
BVR reduces biliverdin, the HO-1 and HO-2 product, to bilirubin. Human biliverdin (BVR) is a
serine/threonine kinase activated by free radicals. It is a leucine zipper (bZip) DNA-binding
protein and a regulatory factor for 8/7-bp AP-1-regulated genes, including HO-1 and ATF-
2/CREB. Presently, small interference (si) RNA constructs were used to investigate the role
of human BVR in sodium arsenite (As)-mediated induction of HO-1 and in cytoprotection
against apoptosis. Activation of BVR involved increased serine/threonine phosphorylation …
serine/threonine kinase activated by free radicals. It is a leucine zipper (bZip) DNA-binding
protein and a regulatory factor for 8/7-bp AP-1-regulated genes, including HO-1 and ATF-
2/CREB. Presently, small interference (si) RNA constructs were used to investigate the role
of human BVR in sodium arsenite (As)-mediated induction of HO-1 and in cytoprotection
against apoptosis. Activation of BVR involved increased serine/threonine phosphorylation …