Individuals with sickle-cell disease (SCD) and transgenic sickle mice expressing human βS
globin exhibit enhanced reactive oxygen species (ROS) production, vascular inflammation,
and episodic vasoocclusion. We hypothesize that reduction of ROS will reduce endothelial-
cell activation and adhesion-molecule expression, thereby inhibiting vasoocclusion. To test
this hypothesis, we measured endothelial-cell activation, adhesion-molecule expression,
and vasoocclusion in sickle mice after administering IV polynitroxyl albumin (PNA), a …