Tumor suppressor activity of neural cell adhesion molecule in colon carcinoma
J Roesler, E Srivatsan, F Moatamed, J Peters… - The American journal of …, 1997 - Elsevier
BACKGROUND AND AIMS: Neural Cell Adhesion Molecule (NCAM) is a well-characterized
member of the immunoglobin superfamily. The structure of NCAM is similar to the tumor
suppressor Deleted in Colon Carcinoma (DCC). NCAM has been found in some epithelial
tissues and plays a role in tumorigenesis of some cancers. The purpose of the present study
was to determine if NCAM is present in normal human colon. Once its presence was
established, its function as a tumor suppressor was investigated. Methods: Colon tumors …
member of the immunoglobin superfamily. The structure of NCAM is similar to the tumor
suppressor Deleted in Colon Carcinoma (DCC). NCAM has been found in some epithelial
tissues and plays a role in tumorigenesis of some cancers. The purpose of the present study
was to determine if NCAM is present in normal human colon. Once its presence was
established, its function as a tumor suppressor was investigated. Methods: Colon tumors …