Resolution of lung inflammation by CD44

P Teder, RW Vandivier, D Jiang, J Liang, L Cohn… - Science, 2002 - science.org
P Teder, RW Vandivier, D Jiang, J Liang, L Cohn, E Puré, PM Henson, PW Noble
Science, 2002science.org
Successful repair after tissue injury and inflammation requires resolution of the inflammatory
response and removal of extracellular matrix breakdown products. We have examined
whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in
resolving lung inflammation. CD44-deficient mice succumb to unremitting inflammation
following noninfectious lung injury, characterized by impaired clearance of apoptotic
neutrophils, persistent accumulation of hyaluronan fragments at the site of tissue injury, and …
Successful repair after tissue injury and inflammation requires resolution of the inflammatory response and removal of extracellular matrix breakdown products. We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation. CD44-deficient mice succumb to unremitting inflammation following noninfectious lung injury, characterized by impaired clearance of apoptotic neutrophils, persistent accumulation of hyaluronan fragments at the site of tissue injury, and impaired activation of transforming growth factor–β1. This phenotype was partially reversed by reconstitution with CD44+ cells, thus demonstrating a critical role for this receptor in resolving lung inflammation.
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