[HTML][HTML] Innate immune recognition of viral infection

T Kawai, S Akira - Nature immunology, 2006 - nature.com
T Kawai, S Akira
Nature immunology, 2006nature.com
Induction of the antiviral innate immune response depends on recognition of viral
components by host pattern-recognition receptors. Members of the Toll-like receptor family
have emerged as key sensors that recognize viral components such as nucleic acids. Toll-
like receptor signaling results in the production of type I interferon and inflammatory
cytokines and leads to dendritic cell maturation and establishment of antiviral immunity.
Cells also express cytoplasmic RNA helicases that function as alternative pattern …
Abstract
Induction of the antiviral innate immune response depends on recognition of viral components by host pattern-recognition receptors. Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids. Toll-like receptor signaling results in the production of type I interferon and inflammatory cytokines and leads to dendritic cell maturation and establishment of antiviral immunity. Cells also express cytoplasmic RNA helicases that function as alternative pattern-recognition receptors through recognition of double-stranded RNA produced during virus replication. These two classes of pattern-recognition receptor molecules are expressed in different intracellular compartments and induce type I interferon responses via distinct signaling pathways.
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