The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity

IP Fraser, H Koziel, RAB Ezekowitz - Seminars in immunology, 1998 - Elsevier
IP Fraser, H Koziel, RAB Ezekowitz
Seminars in immunology, 1998Elsevier
The innate immune system evolved to protect the host in the early phases of an infectious
challenge. The soluble mannose binding protein, and the cell surface mannose receptor are
two key pattern recognition molecules of innate immunity. The ligand binding specificity of
these molecules enables them to differentiate 'self'from 'non-self'. These pattern recognition
capabilities are coupled to effector functions, which enable them to interact with other
molecules of the immune system. In this way, these pattern recognition molecules are able …
The innate immune system evolved to protect the host in the early phases of an infectious challenge. The soluble mannose binding protein, and the cell surface mannose receptor are two key pattern recognition molecules of innate immunity. The ligand binding specificity of these molecules enables them to differentiate ‘self’ from ‘non-self’. These pattern recognition capabilities are coupled to effector functions, which enable them to interact with other molecules of the immune system. In this way, these pattern recognition molecules are able to serve as a link between the innate and adaptive immune systems.
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