Phylogenetic perspectives in innate immunity
JA Hoffmann, FC Kafatos, CA Janeway Jr… - Science, 1999 - science.org
JA Hoffmann, FC Kafatos, CA Janeway Jr, RAB Ezekowitz
Science, 1999•science.orgThe concept of innate immunity refers to the first-line host defense that serves to limit
infection in the early hours after exposure to microorganisms. Recent data have highlighted
similarities between pathogen recognition, signaling pathways, and effector mechanisms of
innate immunity in Drosophila and mammals, pointing to a common ancestry of these
defenses. In addition to its role in the early phase of defense, innate immunity in mammals
appears to play a key role in stimulating the subsequent, clonal response of adaptive …
infection in the early hours after exposure to microorganisms. Recent data have highlighted
similarities between pathogen recognition, signaling pathways, and effector mechanisms of
innate immunity in Drosophila and mammals, pointing to a common ancestry of these
defenses. In addition to its role in the early phase of defense, innate immunity in mammals
appears to play a key role in stimulating the subsequent, clonal response of adaptive …
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.
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