Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats
CK Funk, EP Zorrilla, MJ Lee, KC Rice, GF Koob - Biological psychiatry, 2007 - Elsevier
BACKGROUND: Alcohol dependence is characterized by excessive alcohol consumption,
loss of control over intake, and the presence of a withdrawal syndrome, which includes both
motivational and physical symptoms. Similar to human alcoholics, ethanol-dependent
animals display enhanced anxiety-like behaviors and enhanced ethanol self-administration
during withdrawal, effects hypothesized to result from a dysregulation of corticotropin-
releasing factor (CRF) stress systems. Here, we used an animal model of ethanol …
loss of control over intake, and the presence of a withdrawal syndrome, which includes both
motivational and physical symptoms. Similar to human alcoholics, ethanol-dependent
animals display enhanced anxiety-like behaviors and enhanced ethanol self-administration
during withdrawal, effects hypothesized to result from a dysregulation of corticotropin-
releasing factor (CRF) stress systems. Here, we used an animal model of ethanol …