Altered HPA axis responsivity to metyrapone testing in methadone maintained former heroin addicts with ongoing cocaine addiction

JH Schluger, L Borg, A Ho, MJ Kreek - Neuropsychopharmacology, 2001 - Elsevier
Metyrapone testing, a provocation of hypothalamic-pituitary-adrenocortical (HPA) axis
function, was performed in 39 in-patient subjects: 10 stable methadone-maintained former
heroin addicts without ongoing drug or alcohol abuse or dependence (MM), eight
methadone-maintained former heroin addicts without ongoing drug or alcohol abuse or
dependence other than ongoing cocaine dependence (C-MM), and 21 normal volunteers
(NV). Plasma adrenocorticotrophic hormone (ACTH) levels were determined in samples …