CRF–CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
O George, S Ghozland, MR Azar… - Proceedings of the …, 2007 - National Acad Sciences
Proceedings of the National Academy of Sciences, 2007•National Acad Sciences
Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional
symptoms during abstinence that contribute to a profound craving for nicotine. However, the
neurobiological mechanisms underlying how nicotine produces dependence remains poorly
understood. We demonstrate one mechanism for both the anxiety-like symptoms of
withdrawal and excessive nicotine intake observed after abstinence, through recruitment of
the extrahypothalamic stress peptide corticotropin-releasing factor (CRF) system and …
symptoms during abstinence that contribute to a profound craving for nicotine. However, the
neurobiological mechanisms underlying how nicotine produces dependence remains poorly
understood. We demonstrate one mechanism for both the anxiety-like symptoms of
withdrawal and excessive nicotine intake observed after abstinence, through recruitment of
the extrahypothalamic stress peptide corticotropin-releasing factor (CRF) system and …
Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after abstinence, through recruitment of the extrahypothalamic stress peptide corticotropin-releasing factor (CRF) system and activation of CRF1 receptors. Overactivation of the CRF–CRF1 system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction.
National Acad Sciences