The intestinal microvasculature as a therapeutic target in inflammatory bowel disease
OA Hatoum, J Heidemann… - Annals of the New York …, 2006 - Wiley Online Library
OA Hatoum, J Heidemann, DG Binion
Annals of the New York Academy of Sciences, 2006•Wiley Online LibraryChronic inflammation is a complex biologic process which involves immune as well as non‐
immune cells including the microvasculature and its endothelial lining. Growing evidence
suggests that the microvasculature plays an integral role in the pathophysiology of
inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis). The
microvasculature contributes to chronic inflammation through altered leukocyte recruitment,
impaired perfusion, and angiogenesis leading to tissue remodeling. These diverse areas of …
immune cells including the microvasculature and its endothelial lining. Growing evidence
suggests that the microvasculature plays an integral role in the pathophysiology of
inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis). The
microvasculature contributes to chronic inflammation through altered leukocyte recruitment,
impaired perfusion, and angiogenesis leading to tissue remodeling. These diverse areas of …
Abstract
Chronic inflammation is a complex biologic process which involves immune as well as non‐immune cells including the microvasculature and its endothelial lining. Growing evidence suggests that the microvasculature plays an integral role in the pathophysiology of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis). The microvasculature contributes to chronic inflammation through altered leukocyte recruitment, impaired perfusion, and angiogenesis leading to tissue remodeling. These diverse areas of IBD microvascular biology represent therapeutic targets that are currently undergoing investigation.
Wiley Online Library