A liver tolerates a portal antigen by generating CD11c+ cells, which select Fas ligand+ Th2 cells via apoptosis
T Watanabe, H Katsukura, Y Shirai, M Yamori, T Nishi… - Hepatology, 2003 - Elsevier
Administration of an antigen (Ag) per oral route leads to apoptosis of Ag-specific CD4+ T
cells and to development of Th2 cells expressing Fas ligand (FasL) in the liver. We
determined whether presentation of an ingested Ag in the liver alone was enough to select
these FasL+ Th2 cells and explored how this selection was achieved in the liver. Ovalbumin
(OVA) administered orally was colocalized with class II+ cells in the periportal and
parenchymal area of the liver. On coculture with naive OVA-specific CD4+ T cells, hepatic …
cells and to development of Th2 cells expressing Fas ligand (FasL) in the liver. We
determined whether presentation of an ingested Ag in the liver alone was enough to select
these FasL+ Th2 cells and explored how this selection was achieved in the liver. Ovalbumin
(OVA) administered orally was colocalized with class II+ cells in the periportal and
parenchymal area of the liver. On coculture with naive OVA-specific CD4+ T cells, hepatic …