[HTML][HTML] Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells
W Gao, Y Lu, B El Essawy, M Oukka… - American Journal of …, 2007 - Elsevier
The outcome of T-cell-mediated responses, immunity or tolerance, critically depends on the
balance of cytopathic versus regulatory T (T reg) cells. In the creation of stable tolerance to
MHC incompatible allografts, reducing the unusually large mass of donor-reactive cytopathic
T effector (T eff) cells via apoptosis is often required. Cyclosporine (CsA) blocks activation-
induced cell death (AICD) of T eff cells, and is detrimental to tolerance induction by
costimulation blockade, whereas Rapamycin (RPM) preserves AICD, and augments the …
balance of cytopathic versus regulatory T (T reg) cells. In the creation of stable tolerance to
MHC incompatible allografts, reducing the unusually large mass of donor-reactive cytopathic
T effector (T eff) cells via apoptosis is often required. Cyclosporine (CsA) blocks activation-
induced cell death (AICD) of T eff cells, and is detrimental to tolerance induction by
costimulation blockade, whereas Rapamycin (RPM) preserves AICD, and augments the …