The TIM gene family: emerging roles in immunity and disease
VK Kuchroo, DT Umetsu, RH DeKruyff… - Nature Reviews …, 2003 - nature.com
VK Kuchroo, DT Umetsu, RH DeKruyff, GJ Freeman
Nature Reviews Immunology, 2003•nature.comThe search for cell-surface markers that can distinguish T helper 1 (TH1) cells from TH2 cells
has led to the identification of a new gene family, encoding the T-cell immunoglobulin mucin
(TIM) proteins, some of which are differentially expressed by TH1 and TH2 cells. The role of
the TIM-family proteins in immune regulation is just beginning to emerge. Here, we describe
the various TIM-family members in mice and humans, and discuss the genetic and functional
evidence for their role in regulating autoimmune and allergic diseases.
has led to the identification of a new gene family, encoding the T-cell immunoglobulin mucin
(TIM) proteins, some of which are differentially expressed by TH1 and TH2 cells. The role of
the TIM-family proteins in immune regulation is just beginning to emerge. Here, we describe
the various TIM-family members in mice and humans, and discuss the genetic and functional
evidence for their role in regulating autoimmune and allergic diseases.
Abstract
The search for cell-surface markers that can distinguish T helper 1 (TH1) cells from TH2 cells has led to the identification of a new gene family, encoding the T-cell immunoglobulin mucin (TIM) proteins, some of which are differentially expressed by TH1 and TH2 cells. The role of the TIM-family proteins in immune regulation is just beginning to emerge. Here, we describe the various TIM-family members in mice and humans, and discuss the genetic and functional evidence for their role in regulating autoimmune and allergic diseases.
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