N‐acetylcysteine treatment protects against VEGF‐receptor blockade‐related emphysema
Y Demura, L Taraseviciene‐Stewart… - COPD: Journal of …, 2004 - Taylor & Francis
Y Demura, L Taraseviciene‐Stewart, R Scerbavicius, RM Tuder, NF Voelkel
COPD: Journal of Chronic Obstructive Pulmonary Disease, 2004•Taylor & FrancisAdministration of the VEGF receptor blocker SU5416 to rats causes alveolar septal cell
apoptosis and emphysema; both can be prevented by a superoxide dismutase mimetic.
Here we show that SU5416 induces the expression of heme oxygenase‐1 in the lung tissue
and that administration of antioxidant N‐acetyl‐l‐cysteine protects alveolar septal cells
against apoptosis, as demonstrated by caspase‐3 lung immunohistochemistry, and against
emphysema.
apoptosis and emphysema; both can be prevented by a superoxide dismutase mimetic.
Here we show that SU5416 induces the expression of heme oxygenase‐1 in the lung tissue
and that administration of antioxidant N‐acetyl‐l‐cysteine protects alveolar septal cells
against apoptosis, as demonstrated by caspase‐3 lung immunohistochemistry, and against
emphysema.
Administration of the VEGF receptor blocker SU5416 to rats causes alveolar septal cell apoptosis and emphysema; both can be prevented by a superoxide dismutase mimetic. Here we show that SU5416 induces the expression of heme oxygenase‐1 in the lung tissue and that administration of antioxidant N‐acetyl‐l‐cysteine protects alveolar septal cells against apoptosis, as demonstrated by caspase‐3 lung immunohistochemistry, and against emphysema.
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