Exportable proteins that have significant defects in nascent polypeptide folding or subunit assembly are frequently retained in the endoplasmic reticulum and subject to endoplasmic reticulum‐associated degradation by the ubiquitin‐proteasome system. In addition to this, however, there is growing evidence for post‐endoplasmic reticulum quality control mechanisms in which mutant or non‐native exportable proteins may undergo anterograde transport to the Golgi complex and post‐Golgi compartments before intracellular disposal. In some instances, these proteins may undergo retrograde transport back to the endoplasmic reticulum with re‐targeting to the endoplasmic reticulum‐associated degradation pathway; in other typical cases, they are targeted into the endosomal system for degradation by vacuolar/lysosomal proteases. Such quality control targeting is likely to involve recognition of features more commonly expressed in mutant proteins, but may also be expressed by wild‐type proteins, especially in cells with perturbation of local environments that are essential for normal protein trafficking and stability in the secretory pathway and at the cell surface.