[HTML][HTML] Association of paracellin-1 with ZO-1 augments the reabsorption of divalent cations in renal epithelial cells
A Ikari, N Hirai, M Shiroma, H Harada, H Sakai… - Journal of Biological …, 2004 - ASBMB
Paracellin-1 (PCLN-1) belongs to the claudin family of tight junction proteins and possibly
plays a critical role in the reabsorption of magnesium and calcium. So far, the physiological
properties of PCLN-1 have not been clarified. In the present study, we investigated whether
PCLN-1 is associated with ZO-1. We also investigated whether 45 Ca 2+ transport across
the paracellular barrier is affected by this association. In vitro binding analysis using
glutathione S-transferase fusion protein showed that the C-terminal TRV sequence …
plays a critical role in the reabsorption of magnesium and calcium. So far, the physiological
properties of PCLN-1 have not been clarified. In the present study, we investigated whether
PCLN-1 is associated with ZO-1. We also investigated whether 45 Ca 2+ transport across
the paracellular barrier is affected by this association. In vitro binding analysis using
glutathione S-transferase fusion protein showed that the C-terminal TRV sequence …