[HTML][HTML] Transient impairment of the adaptive response to fasting in FXR-deficient mice

B Cariou, K Van Harmelen, D Duran-Sandoval… - FEBS letters, 2005 - Elsevier
B Cariou, K Van Harmelen, D Duran-Sandoval, T Van Dijk, A Grefhorst, E Bouchaert…
FEBS letters, 2005Elsevier
The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To
determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR−/−)
and wild-type mice were submitted to fasting for 48h. Our results demonstrate that FXR
modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR−/−
mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose
production rate was lower in FXR−/− mice, together with a decrease in hepatic glycogen …
The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR−/−) and wild-type mice were submitted to fasting for 48h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR−/− mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR−/− mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transiently lower in FXR−/−mice after 6h of fasting and was decreased in FXR−/−hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting.
Elsevier