In vivo energy production results largely from the oxidative metabolism of either glucose or
fatty acids. Under diverse physiologic and nutritional conditions, the oxidation of either
glucose or fatty acids may predominate. The nature of the control of the availability and
oxidation of each substrate has been studied extensively for> or= 30 y. The most popular
and enduring hypothesis was proposed by Randle et al in 1963 and is termed the glucose-
fatty acid cycle. This proposal places great significance on the regulation of lipolysis as a …