[HTML][HTML] Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid …
S Yamagishi, D Edelstein, X Du, Y Kaneda… - Journal of Biological …, 2001 - ASBMB
Leptin, a circulating hormone secreted mainly from adipose tissues, is involved in the control
of body weight. The plasma concentrations are correlated with body mass index, and are
reported to be high in patients with insulin resistance, which is one of the major risk factors
for cardiovascular disease. However, the direct effect of leptin on vascular wall cells is not
fully understood. In this study, we investigated the effects of leptin on reactive oxygen
species (ROS) generation and expression of monocyte chemoattractant protein-1 (MCP-1) …
of body weight. The plasma concentrations are correlated with body mass index, and are
reported to be high in patients with insulin resistance, which is one of the major risk factors
for cardiovascular disease. However, the direct effect of leptin on vascular wall cells is not
fully understood. In this study, we investigated the effects of leptin on reactive oxygen
species (ROS) generation and expression of monocyte chemoattractant protein-1 (MCP-1) …