Calcium signalling in platelets and other nonexcitable cells
P Sargeant, SO Sage - Pharmacology & therapeutics, 1994 - Elsevier
P Sargeant, SO Sage
Pharmacology & therapeutics, 1994•ElsevierBy virtue of their biological simplicity and widespread availability, platelets frequently have
been used as a model system to study signal transduction. Such studies have revealed that
changes in intracellular free calcium concentration are central to platelet functioning. The
following article reviews current concepts of platelet structure and function, with particular
emphasis on the mechanisms involved in platelet Ca 2+ signalling.
been used as a model system to study signal transduction. Such studies have revealed that
changes in intracellular free calcium concentration are central to platelet functioning. The
following article reviews current concepts of platelet structure and function, with particular
emphasis on the mechanisms involved in platelet Ca 2+ signalling.
Abstract
By virtue of their biological simplicity and widespread availability, platelets frequently have been used as a model system to study signal transduction. Such studies have revealed that changes in intracellular free calcium concentration are central to platelet functioning. The following article reviews current concepts of platelet structure and function, with particular emphasis on the mechanisms involved in platelet Ca2+ signalling.
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