[HTML][HTML] Silencing of CDX2 expression in colon cancer via a dominant repression pathway
T Hinoi, M Loda, ER Fearon - Journal of Biological Chemistry, 2003 - ASBMB
CDX2 is a caudal-related homeobox transcription factor whose expression in the adult is
normally restricted to intestinal epithelium. Mice heterozygous for germ line Cdx2
inactivation develop intestinal polyps, and the lesions lack Cdx2 expression. Prior studies
indicate some human colon carcinomas also lack CDX2 expression. To address the role of
CDX2 defects in colon cancer development, we analyzed CDX2 expression in 45 primary
colorectal carcinomas. Four carcinomas lacked CDX2 expression, and three others showed …
normally restricted to intestinal epithelium. Mice heterozygous for germ line Cdx2
inactivation develop intestinal polyps, and the lesions lack Cdx2 expression. Prior studies
indicate some human colon carcinomas also lack CDX2 expression. To address the role of
CDX2 defects in colon cancer development, we analyzed CDX2 expression in 45 primary
colorectal carcinomas. Four carcinomas lacked CDX2 expression, and three others showed …