The widespread use of insulin and oral hypoglycaemic agents has increased the incidence
of hypoglycaemic brain damage due to accidental, suicidal, or homicidal overdose.
Hypoglycaemia is capable of damaging the brain in the face of intact cardiac function, but
neuronal necrosis occurs only when the electroencephalogram (EEG) becomes isoelectric.
Neurochemical changes are distinct from ischaemia, and cerebral blood flow is actually
increased, in contrast to cerebral ischaemia. Salient neurochemical changes include an …