Synaptic localization of a functional NADPH oxidase in the mouse hippocampus
MV Tejada-Simon, F Serrano, LE Villasana… - Molecular and Cellular …, 2005 - Elsevier
Superoxide has been shown to be critical for hippocampal long-term potentiation (LTP) and
hippocampus-dependent memory function. A possible source for the generation of
superoxide during these processes is NADPH oxidase. The active oxidase consists of two
membrane proteins, gp91phox and p22phox, and four cytosolic proteins, p40phox,
p47phox, p67phox, and Rac. Upon stimulation, the cytosolic proteins translocate to the
membrane to form a complex with the membrane components, which results in production of …
hippocampus-dependent memory function. A possible source for the generation of
superoxide during these processes is NADPH oxidase. The active oxidase consists of two
membrane proteins, gp91phox and p22phox, and four cytosolic proteins, p40phox,
p47phox, p67phox, and Rac. Upon stimulation, the cytosolic proteins translocate to the
membrane to form a complex with the membrane components, which results in production of …