[HTML][HTML] GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression
C Liu, SW Glasser, H Wan, JA Whitsett - Journal of Biological Chemistry, 2002 - ASBMB
GATA-6, a member of the GATA family of zinc finger domain containing transcription factors,
is expressed in endodermally derived tissues including the lung, where GATA-6 influences
the transcription of target genes, TTF-1, and surfactant proteins. Whereas GATA-6 did not
directly alter expression ofsp-C constructs in HeLa cells, GATA-6 synergistically activated sp-
C gene transcription when co-expressed with TTF-1, supporting the concept that GATA-6
and TTF-1 might directly interact to influence target gene expression. GST-GATA-6 directly …
is expressed in endodermally derived tissues including the lung, where GATA-6 influences
the transcription of target genes, TTF-1, and surfactant proteins. Whereas GATA-6 did not
directly alter expression ofsp-C constructs in HeLa cells, GATA-6 synergistically activated sp-
C gene transcription when co-expressed with TTF-1, supporting the concept that GATA-6
and TTF-1 might directly interact to influence target gene expression. GST-GATA-6 directly …