The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
N Wierup, H Svensson, H Mulder, F Sundler - Regulatory peptides, 2002 - Elsevier
Objectives: Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor
(GHS-R), was recently identified in the stomach. Ghrelin is produced in a population of
endocrine cells in the gastric mucosa, but expression in intestine, hypothalamus and testis
has also been reported. Recent data indicate that ghrelin affects insulin secretion and plays
a direct role in metabolic regulation and energy balance. On the basis of these findings, we
decided to examine whether ghrelin is expressed in human pancreas. Specimens from fetal …
(GHS-R), was recently identified in the stomach. Ghrelin is produced in a population of
endocrine cells in the gastric mucosa, but expression in intestine, hypothalamus and testis
has also been reported. Recent data indicate that ghrelin affects insulin secretion and plays
a direct role in metabolic regulation and energy balance. On the basis of these findings, we
decided to examine whether ghrelin is expressed in human pancreas. Specimens from fetal …