An initial genome scan was performed on 540 individuals from 97 families segregating
bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative.
We report here affected‐sib‐pair (ASP) data on 126 marker loci (≈ 68,000 genotypes)
mapping to chromosomes 4, 7, 9, 18, 19, 20, and 21q, under three affection status models.
Modest increases in identical‐by‐descent (IBD) allele sharing were found at the following
loci: D4S2397 and D4S391 (P< 0.05) on 4p, D4S1647 (P< 0.05) on 4q, D7S1802 and …

As part of the four‐center NIMH Genetics Initiative on Bipolar Disorder we carried out a
genomic scan of chromosomes 3, 5, 15, 16, 17, and 22. Genotyping was performed on a set
of 540 DNAs from 97 families, enriched for affected relative pairs and parents where
available. We report here the results of the initial 74 markers that have been typed on this set
of DNAs. The average distance between markers (θ) was 12.3 cM. Nonparametric analysis
of excess allele sharing among affected sibling pairs used the SIBPAL program of the SAGE …

A report on an initial genome screen on 540 individuals in 97 families was collected as part
of the NIMH Genetics Initiative on Bipolar Disorder. Families were ascertained to be
informative for genetic linkage and underwent a common ascertainment and assessment
protocol at four clinical sites. The sample was genotyped for 65 highly polymorphic markers
from chromosomes 1, 6, 8, 10, and 12. The average intermarker interval was 16 cM.
Genotypic data was analyzed using affected sib pair, multipoint affected sib pair, and …