We recently reported that apolipoprotein AI (apoA-I), the major protein component of high
density lipoprotein, is a selective target for myeloperoxidase (MPO)-catalyzed nitration and
chlorination in both and serum of subjects with cardiovascular disease. We further showed
that the extent of both apoA-I nitration and chlorination correlated with functional impairment
in reverse cholesterol transport activity of the isolated lipoprotein. Herein we used tandem
mass spectrometry to map the sites of MPO-mediated apoA-I nitration and chlorination in …