[HTML][HTML] Interleukin-13 stimulates the transcription of the human α2 (I) collagen gene in human dermal fibroblasts
M Jinnin, H Ihn, K Yamane, K Tamaki - Journal of Biological Chemistry, 2004 - ASBMB
Interleukin (IL)-13 is a novel lymphokine produced by activated Type 2 helper cells. In this
study, we examined the target genes of IL-13 by the cDNA microarray analysis in human
dermal fibroblasts. We focused on the human α2 (I) collagen gene, which was one of the IL-
13-induced genes by the microarray analysis. IL-13 induced type I collagen protein as well
as mRNA in a dose-dependent manner. Actinomycin D, an RNA synthesis inhibitor,
significantly blocked the IL-13-mediated up-regulation of α2 (I) collagen mRNA expression …
study, we examined the target genes of IL-13 by the cDNA microarray analysis in human
dermal fibroblasts. We focused on the human α2 (I) collagen gene, which was one of the IL-
13-induced genes by the microarray analysis. IL-13 induced type I collagen protein as well
as mRNA in a dose-dependent manner. Actinomycin D, an RNA synthesis inhibitor,
significantly blocked the IL-13-mediated up-regulation of α2 (I) collagen mRNA expression …