[HTML][HTML] The early-immediate gene EGR-1 is induced by transforming growth factor-β and mediates stimulation of collagen gene expression
SJ Chen, H Ning, W Ishida, S Sodin-Semrl… - Journal of Biological …, 2006 - ASBMB
Transforming growth factor-β (TGF-β) stimulates collagen synthesis and accumulation, and
aberrant TGF-β signaling is implicated in pathological organ fibrosis. Regulation of type I
procollagen gene (COL1A2) transcription by TGF-β involves the canonical Smad signaling
pathway as well as additional protein and lipid kinases, coactivators, and DNA-binding
transcription factors that constitute alternate non-Smad pathways. By using Affymetrix
microarrays to detect cellular genes whose expression is regulated by Smad3, we identified …
aberrant TGF-β signaling is implicated in pathological organ fibrosis. Regulation of type I
procollagen gene (COL1A2) transcription by TGF-β involves the canonical Smad signaling
pathway as well as additional protein and lipid kinases, coactivators, and DNA-binding
transcription factors that constitute alternate non-Smad pathways. By using Affymetrix
microarrays to detect cellular genes whose expression is regulated by Smad3, we identified …