[HTML][HTML] Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival
B Schäfer, B Marg, A Gschwind, A Ullrich - Journal of Biological Chemistry, 2004 - ASBMB
Cross-talk between G protein-coupled receptor (GPCR) and epidermal growth factor
receptor (EGFR) signaling systems is widely established in a variety of normal and
transformed cell types. Here, we demonstrate that the EGFR transactivation signal requires
metalloproteinase cleavage of epidermal growth factor-like growth factor precursors in
fibroblasts, ACHN kidney, and TccSup bladder carcinoma cells. Furthermore, we present
evidence that blockade of the metalloproteinase-disintegrin tumor necrosis factor-α …
receptor (EGFR) signaling systems is widely established in a variety of normal and
transformed cell types. Here, we demonstrate that the EGFR transactivation signal requires
metalloproteinase cleavage of epidermal growth factor-like growth factor precursors in
fibroblasts, ACHN kidney, and TccSup bladder carcinoma cells. Furthermore, we present
evidence that blockade of the metalloproteinase-disintegrin tumor necrosis factor-α …